In ocular diseases, hyphema is often experienced. Clinically there are many serious complications such as glaucoma, cataract, blood stain to cornea, etc.
Recently, the author has been interested in aspirin which has inhibited action of platelet aggregation and prolongation of bleeding time when it is used systemically.
But everyone don´t know what influence on the absorption of the anterior chamber hemorrhages when we use it as the subconjunctival or intracameral routes.
In this study, simulated anterior chamber hemorrhages were produced by intracameral injection of 0.1 cc autogenous 51Cr labeled blood through the limbus in 28 rabbits eyes.
Thereafter, the author treated the rabbits with aspirin by subconjunctival (40 mg/0.2 cc), intracameral (20 mg/0. 1 cc), and intramuscular injection (200 mg/cc) everyday for 10 days.
All experimental groups were measured and recorded the changes of radioactivity of the eyes with scintillation counter for 10 days.
The final results were summarized as follows;
1) The time required for 505vo of the injected radioactivity to disappear after experimental hyphema was 18 hours in the intracameral injection group, within 48 hours in subconjunctival injection group, over 72 hours in both control and intramuscular injection groups.
2) The rates of removal of the radioactivity from the anterior chamber didn´t make any difference between control and intramuscular injection groups.
3) In general, the intracameral and subconjunctival injection groups showed faster rate of absorption of blood from the anterior chamber than the other two groups.
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